FTO: linking m6A demethylation to adipogenesis

Cell Res. 2015 Jan;25(1):3-4. doi: 10.1038/cr.2014.162. Epub 2014 Dec 5.


Polymorphism of the FTO gene encoding an N(6)-methyladenosine (m(6)A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.

Publication types

  • Comment

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adipocytes / cytology*
  • Adipogenesis*
  • Animals
  • Mixed Function Oxygenases / metabolism*
  • Oxo-Acid-Lyases / metabolism*
  • RNA Splicing*
  • RNA, Messenger / genetics*


  • RNA, Messenger
  • Mixed Function Oxygenases
  • Oxo-Acid-Lyases
  • Adenosine