Past experience resets behavior: CaMK takes the heat

Neuron. 2014 Dec 3;84(5):883-5. doi: 10.1016/j.neuron.2014.11.014.


How past experiences reshape behavior is not well understood. In this issue, two studies (Schild et al., 2014; Yu et al., 2014) dissected the molecular mechanisms underlying experience-dependent plasticity in thermosensory behavior. They show that Ca(2+)/calmodulin-dependent kinase I (CaMKI) regulates thermal preferences according to past experience.