Hepatocyte growth factor: A regulator of inflammation and autoimmunity

Autoimmun Rev. 2015 Apr;14(4):293-303. doi: 10.1016/j.autrev.2014.11.013. Epub 2014 Dec 1.


Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases. HGF was reported to prevent and attenuate disease progression by influencing multiple pathophysiological processes involved in inflammatory and immune response, including cell migration, maturation, cytokine production, antigen presentation, and T cell effector function. In this review, we discuss the actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases.

Keywords: Autoimmune regulator; Autoimmunity; HGF; Inflammation; Therapy; c-Met.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmunity*
  • Hepatocyte Growth Factor / metabolism*
  • Humans
  • Inflammation / immunology*
  • Signal Transduction


  • Hepatocyte Growth Factor