Koschei the immortal and anti-aging drugs

Cell Death Dis. 2014 Dec 4;5(12):e1552. doi: 10.1038/cddis.2014.520.

Abstract

In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamycin? And was rapamycin (or another rapalog) combined with commonly available drugs such as metformin, aspirin, propranolol, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors.

Publication types

  • Review

MeSH terms

  • Aging / drug effects*
  • Aging / metabolism
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology
  • Aspirin / pharmacology
  • Caloric Restriction*
  • Exercise
  • Folklore
  • Gene Expression
  • Glucose / metabolism
  • Humans
  • Insulin Resistance
  • Longevity / drug effects*
  • Longevity / physiology
  • Metformin / pharmacology
  • Propranolol / pharmacology
  • Russia
  • Sirolimus / pharmacology*
  • TOR Serine-Threonine Kinases / antagonists & inhibitors*
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Metformin
  • Propranolol
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • Glucose
  • Aspirin
  • Sirolimus