Background: The rs10761482 polymorphism of the ANK3 gene has been associated with the occurrence of schizophrenia.
Aim: Assess the relationship between the ANK3 gene and schizophrenia in individuals of Uyghurian descent.
Methods: A total of 630 patients with schizophrenia and 535 healthy controls of Uyghur descent were genotyped for the ANK3 gene rs10761482 locus using Taqman probe technology. SHEsis and SPSS17.0 software were used for data analysis.
Results: There were no significant differences in the genotype or allele frequencies between the case group and control group. Within the case group there was no relationship between gender or age of onset of schizophrenia and the genotype or allele frequencies. Separate analyses among men and among women also failed to identify significant differences in the allele and genotype frequencies between cases and controls or between patients with adolescent-onset schizophrenia and those with adult-onset schizophrenia.
Conclusion: Our findings do not support previous reports about the relationship of the ANK3 gene and schizophrenia. In the Uyghur nationality group recruited for this study there was no significant association between the ANK3 gene rs10761482 polymorphism and schizophrenia. If these results are replicated in further studies, then the focus should change to understanding why this widely acknowledged association does not exist in this particular ethnic group.
背景: ANK3基因rs10761482多态性已被发现与精神 分裂症的发生相关联。
目的: 评估新疆维吾尔族人群ANK3基因和精神分裂 症之间的关联。
方法: 使用Taqman探针技术对630例新疆维吾尔族 精神分裂症患者和535名新疆维吾尔族健康人群进行 ANK3 基因rs10761482位点的基因分型。采用SHEsis 和SPSS17.0软件进行数据分析。
结果: 病例组和对照组之间的基因型和等位基因频率 无显著差异。在病例组，性别或精神分裂症发病年龄 与基因型或等位基因频率之间没有显著关联。将男性 和女性单独分析，病例组与对照组之间的等位基因和 基因型频率均未发现显著差异，青春期发病与成年后 发病的精神分裂症患者之间的等位基因和基因型频率 也无显著差异。
结论: 我们的研究结果不支持以往ANK3基因与精神 分裂症有关联的报告。本研究招募的维吾尔族人群中， ANK3 基因rs10761482多态性与精神分裂症之间没有 显著关联。如果这些结果在进一步的研究中得到证实， 那么研究重点将转而了解为什么在这个特定的族群中 不存在上述已经被广泛认可的关联。
Keywords: ANK3 gene; China; Uyghur nationality; association studies; rs10761482 polymorphism; schizophrenia.