Time to overcome the high, long, and bumpy free energy barrier in a multi-stage process: the generalized steady-state approach

J Phys Chem B. 2015 Jan 8;119(1):158-63. doi: 10.1021/jp5109703. Epub 2014 Dec 19.


This paper presents a simple but general analytical estimate of the characteristic time of crossing a long, high, and arbitrary bumpy free energy barrier in the course of a sequential (one-dimensional) chemical, biochemical, or physical reaction. This estimate is based on a generalized steady-state approach developed in this paper.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Thermodynamics*
  • Time Factors