Role of oral doxycycline and large diameter bandage contact lens in the management of early post-trabeculectomy bleb leak

BMJ Case Rep. 2014 Dec 5:2014:bcr2014208008. doi: 10.1136/bcr-2014-208008.

Abstract

A 27-year-old man with juvenile open angle glaucoma and medically uncontrolled intraocular pressure (IOP) underwent a trabeculectomy with mitomycin C in his right eye. One week postoperatively, he developed ischaemic necrosis of the conjunctiva with a bleb leak. This was managed conservatively with oral doxycycline 100 mg twice daily along with a topical low-dose steroid, antibiotic and cycloplegic and a large diameter bandage contact lens (BCL). There was dramatic improvement in the bleb appearance, the necrosis healed and the leak resolved. The patient had well-controlled IOP with a diffuse healthy bleb at 4 weeks, which was maintained at 2 years. This case illustrates the utility and importance of oral doxycycline in the management of early post-trabeculectomy conjunctival necrosis and the use of BCL in the management of a bleb leak. This safe and non-invasive method not only hastened the recovery but also helped in maintaining good bleb function.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Adult
  • Anastomotic Leak / diagnosis
  • Anastomotic Leak / therapy*
  • Bandages
  • Conjunctiva / pathology*
  • Contact Lenses*
  • Doxycycline / administration & dosage*
  • Female
  • Follow-Up Studies
  • Glaucoma, Open-Angle / diagnosis
  • Glaucoma, Open-Angle / surgery*
  • Humans
  • Necrosis / etiology
  • Necrosis / pathology
  • Ophthalmic Solutions
  • Postoperative Complications / diagnosis
  • Postoperative Complications / therapy
  • Risk Assessment
  • Role
  • Steroids / administration & dosage
  • Tonometry, Ocular / methods
  • Trabeculectomy / adverse effects*
  • Trabeculectomy / methods
  • Treatment Outcome

Substances

  • Ophthalmic Solutions
  • Steroids
  • Doxycycline