Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 86 (16), 6116-20

Dissection of Functional Domains of Adenovirus DNA Polymerase by Linker-Insertion Mutagenesis

Affiliations

Dissection of Functional Domains of Adenovirus DNA Polymerase by Linker-Insertion Mutagenesis

M Chen et al. Proc Natl Acad Sci U S A.

Abstract

Linker-insertion mutations were introduced into the cloned adenovirus DNA polymerase gene and the functional effects on the initiation and elongation of DNA in vitro were measured. Essential regions of the polymerase appear to be scattered in patches across the entire molecule and are not limited to the five regions of homology shared with a variety of other replicating polymerases. Thus, the adenovirus DNA polymerase presumably contains active sites that must be formed by distant interactions across the polymerase molecule.

Similar articles

See all similar articles

Cited by 14 PubMed Central articles

See all "Cited by" articles

References

    1. Cell. 1977 Jun;11(2):283-95 - PubMed
    1. Virology. 1973 Nov;56(1):54-69 - PubMed
    1. Nucleic Acids Res. 1979 Mar;6(3):1025-39 - PubMed
    1. Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 - PubMed
    1. Cell. 1981 Feb;23(2):497-508 - PubMed

Publication types

Substances

Feedback