Comparison of two mouthrinses in relation to salivary flow and perceived dryness

Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Jan;119(1):59-64. doi: 10.1016/j.oooo.2014.09.027. Epub 2014 Oct 2.

Abstract

Objective: To compare measures of dry mouth following extended use of an alcohol-based mouthrinse (LISTERINE Antiseptic [LA]) and a non-alcohol-based mouthrinse (Crest Pro-Health Rinse [CPH]) on healthy adults with "normal" salivary flow.

Methods: This single-site, randomized, observer-blinded, parallel study compared unstimulated whole salivary flow and perceived dryness following daily use at weeks 4 and 12 versus baseline. Noninferiority, between-treatment flow comparisons (0.15 mL/min margin), and between-treatment comparisons of the mean Bluestone Mouthfeel Questionnaire (BMQ) visual analog scale scores were made using analysis of covariance.

Results: Measures of dry mouth were comparable between mouthrinses, as demonstrated by both noninferiority of LA versus CPH flow (P < .001) and no significant differences between groups in the BMQ measures at 4 or 12 weeks.

Conclusions: Extended use of an alcohol-based mouthrinse is no more likely to cause reduction in salivary flow or perceived dryness in individuals with normal salivary flow compared with a non-alcohol-based mouthrinse (CPH).

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cetylpyridinium / adverse effects*
  • Drug Combinations
  • Female
  • Humans
  • Male
  • Mouthwashes / adverse effects*
  • Salicylates / adverse effects*
  • Salivation / drug effects*
  • Surveys and Questionnaires
  • Terpenes / adverse effects*
  • Xerostomia / chemically induced*

Substances

  • Crest Pro-Health mouthrinse
  • Drug Combinations
  • Mouthwashes
  • Salicylates
  • Terpenes
  • Listerine
  • Cetylpyridinium