ISWI chromatin remodeling complexes in the DNA damage response

Cell Cycle. 2014;13(19):3016-25. doi: 10.4161/15384101.2014.956551.

Abstract

Regulation of chromatin structure is an essential component of the DNA damage response (DDR), which effectively preserves the integrity of DNA by a network of multiple DNA repair and associated signaling pathways. Within the DDR, chromatin is modified and remodeled to facilitate efficient DNA access, to control the activity of repair proteins and to mediate signaling. The mammalian ISWI family has recently emerged as one of the major ATP-dependent chromatin remodeling complex families that function in the DDR, as it is implicated in at least 3 major DNA repair pathways: homologous recombination, non-homologous end-joining and nucleotide excision repair. In this review, we discuss the various manners through which different ISWI complexes regulate DNA repair and how they are targeted to chromatin containing damaged DNA.

Keywords: ACF1; ACF1, ATP-utilizing Chromatin assembly and remodeling Factor 1; ATP-dependent chromatin remodeling; BER, Base Excision Repair; DDR, DNA Damage Response; DNA damage response; DSB, Double Strand Break; GG-NER, Global Genome Nucleotide Excision Repair; HR, Homologous Recombination; Homologous Recombination; ISWI; ISWI, Imitation SWItch; MRN, MRE11/Rad50/NBS1; NER, Nucleotide Excision Repair; NHEJ, Non-Homologous End Joining; Non-Homologous End-Joining; Nucleotide Excision Repair; PAR, Poly(ADP-Ribose); RNApolII, RNA Polymerase II; RSF1, Remodeling and Spacing Factor 1; SMARCA, SWI-SNF-related Matrix-associated Actin-dependent Regulator of Chromatin A; SMARCA5/SNF2H; TC-NER, Transcription-Coupled Nucleotide Excision Repair; WSTF; WSTF, Williams Syndrome Transcription Factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / chemistry
  • Adenosine Triphosphatases / metabolism*
  • Animals
  • Chromatin / chemistry
  • Chromatin / metabolism*
  • Chromatin Assembly and Disassembly
  • DNA Breaks, Double-Stranded
  • DNA Repair*
  • Drosophila / metabolism
  • Histones / metabolism
  • MicroRNAs / metabolism
  • Signal Transduction

Substances

  • Chromatin
  • Histones
  • MicroRNAs
  • Adenosine Triphosphatases

Grant support

This work was supported by the Association for International Cancer Research (grant number 08-0084), the Netherlands Organization for Scientific Research (ALW grant numbers 863.08.022, 854.11.002 and ZonMW 912.12.132) and the European Research Council Advanced Grants (grant number 340988 – ERC_ID to WV).