Peyronie's disease (PD) is marked by severe penile curved deformity and/or abnormal sexual function. The study aim was to determine the clinical efficacy of a new surgical procedure for PD, aimed at restoration of normal erection and improvement of the coital function. For this purpose, 5 cases of PD with erectile pain and curved deformity, aged 26-49 (median: 37.2) years, who previously underwent penile induration resection and autologous testicular tunica vaginalis patch grafting were retrospectively analyzed to determine the clinical efficacy of the treatment and impact on the postoperative sexual function. After follow-up for more than 12 months, all patients experienced normal penile erection without the erectile pain, and they were all fully satisfied with their sexual performance. No testicular atrophy, torsion, or necrosis of the operative side was observed. The curved deformity while penile erection was satisfactorily corrected, and the 4 out of 5 (80 %) cases displayed completely normal appearance of the penile erection. However, the remaining one case experienced local slake and bulging of the repair site while penile erection. We, therefore, concluded that the testicular tunica vaginalis patch grafting was a safe, convenient, economical, and effective procedure for the treatment of PD.