Biology and treatment of myeloma

Clin Lymphoma Myeloma Leuk. 2014 Sep;14 Suppl:S65-70. doi: 10.1016/j.clml.2014.06.011.

Abstract

In recent years significant progress has been made in the understanding of multiple myeloma (MM) biology and its treatment. Current strategies for the treatment of MM involve the concept of sequential blocks of therapy given as an induction followed by consolidation and maintenance. In an age characterized by emerging and more powerful laboratory techniques, it is of primary importance to understand the biology of MM and how this biology can guide the development of new treatment strategies. This review focuses on the genetic basis of myeloma, including the most common genetic abnormalities and pathways affected and the effects that these have on MM treatment strategies. MM biology is discussed also in the light of more recent theory of intraclonal heterogeneity.

Keywords: Genetic; Intraclonal heterogeneity; Multiple myeloma; Sequential treatment; Treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Clinical Protocols
  • Genetic Predisposition to Disease
  • Humans
  • Multiple Myeloma / diagnosis
  • Multiple Myeloma / etiology*
  • Multiple Myeloma / therapy*
  • NF-kappa B / metabolism
  • Prognosis
  • Proto-Oncogene Proteins c-myc / genetics
  • Proto-Oncogene Proteins c-myc / metabolism
  • ras Proteins / genetics
  • ras Proteins / metabolism

Substances

  • NF-kappa B
  • Proto-Oncogene Proteins c-myc
  • ras Proteins