Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives

Bioorg Med Chem Lett. 2015 Jan 15;25(2):313-6. doi: 10.1016/j.bmcl.2014.11.042. Epub 2014 Nov 22.


5-(4'-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity.

Keywords: 5-(4′-Methoxyphenyl)-oxazole; Caenorhabditis elegans; Hatch inhibition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antinematodal Agents / chemical synthesis*
  • Antinematodal Agents / pharmacology*
  • Bacteria / drug effects
  • Caenorhabditis elegans / drug effects*
  • Caenorhabditis elegans / growth & development*
  • Cells, Cultured
  • Fungi / drug effects
  • Germ Cells / cytology
  • Germ Cells / drug effects
  • HeLa Cells
  • Humans
  • Molecular Structure
  • Oxazoles / chemistry*
  • Structure-Activity Relationship


  • Antinematodal Agents
  • Oxazoles