Topical cidofovir-induced acute kidney injury in two severely immunocompromised patients with refractory multidrug-resistant herpes simplex virus infections

Ila M Saunders; Amit Lahoti; Roy F Chemaly; Cynthia Trevino; Michael Westmoreland; Chitra Hosing

doi:10.1177/1078155214560921

Topical cidofovir-induced acute kidney injury in two severely immunocompromised patients with refractory multidrug-resistant herpes simplex virus infections

J Oncol Pharm Pract. 2016 Apr;22(2):325-31. doi: 10.1177/1078155214560921. Epub 2014 Dec 7.

Authors

Ila M Saunders¹, Amit Lahoti², Roy F Chemaly³, Cynthia Trevino⁴, Michael Westmoreland⁵, Chitra Hosing⁴

Affiliations

¹ UC San Diego Skaggs School of Pharmacy & Pharmaceutical Sciences, La Jolla, CA, USA (At the time of submission, Ila M Saunders was a Clinical Pharmacy Specialist in the Division of Pharmacy at The University of Texas MD Anderson Cancer Center, Houston, TX, USA) isaunders@ucsd.edu.
² Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³ Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁴ Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁵ Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

PMID: 25488905
DOI: 10.1177/1078155214560921

Abstract

Cidofovir, a nucleoside analog of deoxycytidine monophosphate, is a water-soluble polar molecule that exhibits antiviral activity against a broad range of DNA viruses. Cidofovir for injection is approved for the treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. The safety and efficacy of topical cidofovir has been described in a limited number of patients. We present two cases of multidrug-resistant herpes simplex virus infections that responded to topical cidofovir therapy yet resulted in irreversible acute kidney injury.

Keywords: Topical cidofovir; acute kidney injury; herpes simplex virus; immmunocompromised.

Publication types

Case Reports

MeSH terms

Acute Kidney Injury / chemically induced*
Acute Kidney Injury / diagnosis
Acute Kidney Injury / immunology
Administration, Topical
Antiviral Agents / administration & dosage
Antiviral Agents / adverse effects*
Cidofovir
Cytosine / administration & dosage
Cytosine / adverse effects
Cytosine / analogs & derivatives*
Drug Resistance, Multiple, Viral / drug effects*
Drug Resistance, Multiple, Viral / immunology
Herpes Simplex / diagnosis
Herpes Simplex / drug therapy*
Herpes Simplex / immunology
Humans
Immunocompromised Host / drug effects*
Immunocompromised Host / immunology
Male
Middle Aged
Organophosphonates / administration & dosage
Organophosphonates / adverse effects*

Substances

Antiviral Agents
Organophosphonates
Cytosine
Cidofovir