Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression

Cancer Cell. 2014 Dec 8;26(6):773-774. doi: 10.1016/j.ccell.2014.11.020.


In this issue of Cancer Cell, Tiberi and colleagues describe a tumor-suppressor role for BCL6. In the cerebellum, BCL6 is required for the transition from proliferative precursor cell to a more differentiated immature neuron through repressing the expression of Hedgehog effectors, thus controlling a pathway that is aberrantly activated in medulloblastoma.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Medulloblastoma / pathology*
  • Neurogenesis*
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-bcl-6
  • Repressor Proteins / metabolism*
  • Signal Transduction*
  • Sirtuin 1 / metabolism*


  • BCL6 protein, human
  • BCOR protein, human
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-6
  • Repressor Proteins
  • Sirtuin 1