Epigenetic noise fuels cancer evolution

Cancer Cell. 2014 Dec 8;26(6):775-776. doi: 10.1016/j.ccell.2014.11.003.


Cancer is a disease of the genome and the epigenome. Previous studies have shown that genomic changes such as mutations, copy number variation, and genomic rearrangements drive cancer evolution. In this issue of Cancer Cell, Landau and colleagues add epigenomic changes, specifically locally disordered DNA methylation, to cancer's evolutionary trajectory.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • B-Lymphocytes / metabolism*
  • DNA Methylation*
  • Epigenesis, Genetic*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*