SnapShot: Medulloblastoma

Cancer Cell. 2014 Dec 8;26(6):940-940.e1. doi: 10.1016/j.ccell.2014.11.015.

Abstract

Medulloblastoma (MB) is the most common malignant brain tumor in children, where one-third of patients succumb to their disease. This SnapShot describes the classification of MB subgroups, historically by histopathology and currently based on genomic information. Genomics-based classification has identified four major subgroups and provides greater opportunity for developing targeted therapies more successful than current conventional therapy.

MeSH terms

  • Animals
  • Cerebellar Neoplasms / genetics
  • Cerebellar Neoplasms / pathology*
  • Cerebellar Neoplasms / therapy
  • Epigenesis, Genetic
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Medulloblastoma / genetics
  • Medulloblastoma / pathology*
  • Medulloblastoma / therapy
  • Mice
  • Neoplasms, Experimental