An open investigation of the reproducibility of cancer biology research

Elife. 2014 Dec 10:3:e04333. doi: 10.7554/eLife.04333.


It is widely believed that research that builds upon previously published findings has reproduced the original work. However, it is rare for researchers to perform or publish direct replications of existing results. The Reproducibility Project: Cancer Biology is an open investigation of reproducibility in preclinical cancer biology research. We have identified 50 high impact cancer biology articles published in the period 2010-2012, and plan to replicate a subset of experimental results from each article. A Registered Report detailing the proposed experimental designs and protocols for each subset of experiments will be peer reviewed and published prior to data collection. The results of these experiments will then be published in a Replication Study. The resulting open methodology and dataset will provide evidence about the reproducibility of high-impact results, and an opportunity to identify predictors of reproducibility.

Keywords: human; human biology; medicine; methodology; mouse; open science; replication; reproducibility; reproducibility project: cancer biology.

MeSH terms

  • Biomedical Research*
  • Humans
  • Neoplasms*
  • Reproducibility of Results

Grants and funding

The Reproducibility Project: Cancer Biology is funded by the Laura and John Arnold Foundation, provided to the Center for Open Science in collaboration with Science Exchange. The funder had no role in study design or the decision to submit the work for publication.