Non-histone protein methylation as a regulator of cellular signalling and function

Nat Rev Mol Cell Biol. 2015 Jan;16(1):5-17. doi: 10.1038/nrm3915. Epub 2014 Dec 10.

Abstract

Methylation of Lys and Arg residues on non-histone proteins has emerged as a prevalent post-translational modification and as an important regulator of cellular signal transduction mediated by the MAPK, WNT, BMP, Hippo and JAK-STAT signalling pathways. Crosstalk between methylation and other types of post-translational modifications, and between histone and non-histone protein methylation frequently occurs and affects cellular functions such as chromatin remodelling, gene transcription, protein synthesis, signal transduction and DNA repair. With recent advances in proteomic techniques, in particular mass spectrometry, the stage is now set to decode the methylproteome and define its functions in health and disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromatin Assembly and Disassembly / physiology*
  • DNA Repair / physiology*
  • Extracellular Signal-Regulated MAP Kinases / genetics
  • Extracellular Signal-Regulated MAP Kinases / metabolism
  • Humans
  • MAP Kinase Signaling System / physiology*
  • Methylation
  • Protein Biosynthesis / physiology*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • STAT Transcription Factors / genetics
  • STAT Transcription Factors / metabolism
  • Transcription, Genetic / physiology*
  • Wnt Proteins / genetics
  • Wnt Proteins / metabolism
  • Wnt Signaling Pathway / physiology*

Substances

  • STAT Transcription Factors
  • Wnt Proteins
  • Hippo protein, human
  • Protein-Serine-Threonine Kinases
  • Extracellular Signal-Regulated MAP Kinases