This review summarizes briefly literature reports on nucleoside analogues containing five-membered aglycones based on imidazole-4-carboxamide, 1,2,4-triazole-3-carboxamide or 1,2,3-triazole-4-carboxamide structural motifs, which exhibit diverse therapeutically useful or promising biological properties. We do not describe synthetic approaches but try to present the essential activities of compounds and their established or postulated mechanisms of action.
Keywords: 1,2,3-Triazole nucleosides; 1,2,4-Triazole nucleosides; Imidazole nucleosides; Mechanism of action; Ribavirin.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.