Evaluation of body adiposity index as a predictor of aortic stiffness in multi-ethnic Asian population with type 2 diabetes

Diab Vasc Dis Res. 2015 Mar;12(2):111-8. doi: 10.1177/1479164114554609. Epub 2014 Dec 9.


Cardiovascular disease is the leading cause of morbidity and mortality in type 2 diabetes mellitus. We evaluated the predictive ability of the recently developed body adiposity index for aortic stiffness, an intermediate endpoint of cardiovascular disease, in a cross-sectional multi-ethnic Asian type 2 diabetes mellitus cohort (N = 1408). AS was estimated using carotid-femoral pulse wave velocity measured by applanation tonometry. Body adiposity index was computed as hip circumference/(height)(1.5) - 18. Compared to body mass index, waist circumference and visceral fat area, body adiposity index displayed the weakest association with pulse wave velocity (r = 0.077, 0.096, 0.134 and 0.058, respectively; all p < 0.05). Interestingly, the relationship between measurements of obesity and pulse wave velocity was ethnic dependent - body mass index, body adiposity index, waist circumference and visceral fat area consistently predicted pulse wave velocity only in Indians but not others. In multi-variable analysis, body mass index was a significant determinant of pulse wave velocity in all ethnicities. In conclusion, body adiposity index is a weak predictor of aortic stiffness (when compared with body mass index) in Asians with type 2 diabetes mellitus.

Keywords: Aortic stiffness; body adiposity index; obesity; type 2 diabetes.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiposity / ethnology*
  • Aged
  • Body Height
  • Body Mass Index
  • Body Weights and Measures*
  • Cardiovascular Diseases / ethnology*
  • Cardiovascular Diseases / physiopathology
  • Chi-Square Distribution
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / ethnology*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Electric Impedance
  • Female
  • Hip / physiopathology*
  • Humans
  • Intra-Abdominal Fat / physiopathology
  • Linear Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Obesity / ethnology*
  • Obesity / physiopathology
  • Predictive Value of Tests
  • Prognosis
  • Pulse Wave Analysis
  • Risk Assessment
  • Risk Factors
  • Singapore / epidemiology
  • Vascular Stiffness*
  • Waist Circumference