Brain structure in narcissistic personality disorder: a VBM and DTI pilot study

Psychiatry Res. 2015 Feb 28;231(2):184-6. doi: 10.1016/j.pscychresns.2014.11.001. Epub 2014 Nov 8.


We analysed T1-weighted MRI scans using voxel-based morphometry (VBM) and tract-based spatial statistics (TBBS) on diffusion tensor images (DTI) in narcissistic personality disorder (NaPD) patients and healthy controls. Grey matter deficits include right prefrontal and bilateral medial prefrontal/anterior cingulate cortices, and decreased fractional anisotropy in right frontal lobe white matter.

Keywords: Diffusion tensor imaging (DTI); Narcissistic personality disorder; Voxel-based morphometry (VBM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diffusion Tensor Imaging / methods
  • Frontal Lobe / pathology*
  • Gray Matter / pathology*
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Male
  • Narcissism*
  • Personality Disorders / pathology*
  • Pilot Projects
  • White Matter / pathology*
  • Young Adult