Role of education and differentiation in determining the potential of natural killer cells to respond to antibody-dependent stimulation

AIDS. 2014 Nov 28;28(18):2781-6. doi: 10.1097/QAD.0000000000000489.


Antibody-dependent activation of natural killer (NK) cells might facilitate protective outcomes in the context of HIV exposure or infection. Antibody-dependent activation is heightened in NK cells educated by interactions between killer immunoglobulin-like receptors (KIRs) and their major histocompatibility complex class I ligands during ontogeny. Differentiated NK cells, defined as CD57, also exhibit enhanced antibody-dependent responsiveness. Although KIRs are more frequently expressed on CD57 NK cells, the presented data suggest education and differentiation make independent contributions to NK cell anti-HIV envelope antibody-dependent activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • HIV Antibodies / immunology*
  • HIV Infections / immunology*
  • Humans
  • Killer Cells, Natural / immunology*
  • Lymphocyte Activation


  • HIV Antibodies