Comprehensive dietary education in treated gout patients does not further improve serum urate

Intern Med J. 2015 Feb;45(2):189-94. doi: 10.1111/imj.12661.


Background/aim: This study aims to investigate the influence of dietary education in patients with gout on a stable dose of urate-lowering therapy (ULT).

Methods: Males and females aged >18 years with a history of gout, receiving an appropriate and stable dose of ULT, were recruited from two tertiary hospitals and randomised into two groups. The control group received basic advice regarding the importance of compliance with therapy and the benefit of weight loss. The intervention group received comprehensive dietary advice based on the British Society of Rheumatology Guidelines. Both groups received education at baseline and 3 months. Serum urate was measured at baseline, 3 months and 6 months, and a questionnaire was completed at baseline and at 6 months. The primary outcome of the study was to compare the change in serum urate between groups.

Results: Thirty patients were recruited into the study. There was no difference in serum urate between the control and intervention group at 6 months (0.29 mmol/L vs 0.29 mmol/L at baseline and 0.27 mmol/L vs 0.30 mmol/L at 6 months). The intervention group showed a statistically significant improvement in knowledge (8/13 in control group at baseline to 9/13 at 6 months vs 8/13 in intervention group at baseline to 12/13 at 6 months, P < 0.05) and self-reported dietary modification (1 in control vs 7 in intervention P < 0.05) at 6 months.

Conclusion: This randomised controlled trial shows that in patients on ULT, providing education on diet does not lead to any clinically significant difference in serum urate at 6 months.

Keywords: diet; education; gout; therapy; uric acid.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Allopurinol / therapeutic use
  • Australia
  • Female
  • Gout / blood
  • Gout / diet therapy*
  • Gout / drug therapy*
  • Gout Suppressants / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Patient Compliance / statistics & numerical data
  • Patient Education as Topic / methods*
  • Patient Satisfaction / statistics & numerical data
  • Prognosis
  • Prospective Studies
  • Recurrence
  • Risk Assessment
  • Severity of Illness Index
  • Single-Blind Method
  • Treatment Outcome
  • Uric Acid / blood*


  • Gout Suppressants
  • Uric Acid
  • Allopurinol