Fructose containing sugars do not raise blood pressure or uric acid at normal levels of human consumption

J Clin Hypertens (Greenwich). 2015 Feb;17(2):87-94. doi: 10.1111/jch.12457. Epub 2014 Dec 15.


The impact of fructose, commonly consumed with sugars by humans, on blood pressure and uric acid has yet to be defined. A total of 267 weight-stable participants drank sugar-sweetened milk every day for 10 weeks as part of their usual, mixed-nutrient diet. Groups 1 and 2 had 9% estimated caloric intake from fructose or glucose, respectively, added to milk. Groups 3 and 4 had 18% of estimated caloric intake from high fructose corn syrup or sucrose, respectively, added to the milk. Blood pressure and uric acid were determined prior to and after the 10-week intervention. There was no effect of sugar type on either blood pressure or uric acid (interaction P>.05), and a significant time effect for blood pressure was noted (P<.05). The authors conclude that 10 weeks of consumption of fructose at the 50th percentile level, whether consumed as pure fructose or with fructose-glucose-containing sugars, does not promote hyperuricemia or increase blood pressure.

Trial registration: NCT01797042.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Blood Pressure / drug effects*
  • Blood Pressure / physiology
  • Body Weight / drug effects
  • Dietary Carbohydrates / adverse effects
  • Dietary Carbohydrates / pharmacology*
  • Energy Intake / physiology*
  • Female
  • Fructose / adverse effects
  • Fructose / pharmacology*
  • Humans
  • Hypertension / etiology
  • Hypertension / physiopathology
  • Hyperuricemia / etiology
  • Hyperuricemia / physiopathology
  • Male
  • Middle Aged
  • Prospective Studies
  • Single-Blind Method
  • Sucrose / pharmacology
  • Treatment Outcome
  • Uric Acid / blood*


  • Dietary Carbohydrates
  • Uric Acid
  • Fructose
  • Sucrose

Associated data