Eco-friendly aqueous core surface-modified nanocapsules

C Carbone; T Musumeci; M R Lauro; G Puglisi

doi:10.1016/j.colsurfb.2014.11.038

Eco-friendly aqueous core surface-modified nanocapsules

Colloids Surf B Biointerfaces. 2015 Jan 1:125:190-6. doi: 10.1016/j.colsurfb.2014.11.038. Epub 2014 Dec 2.

Authors

C Carbone¹, T Musumeci², M R Lauro³, G Puglisi⁴

Affiliations

¹ Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i Research Centre On Ocular Nanotechnology, University of Catania, Catania, Italy. Electronic address: ccarbone@unict.it.
² Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i Research Centre On Ocular Nanotechnology, University of Catania, Catania, Italy. Electronic address: teresa.musumeci@unict.it.
³ Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084 Fisciano (SA), Italy.
⁴ Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i Research Centre On Ocular Nanotechnology, University of Catania, Catania, Italy.

PMID: 25497291
DOI: 10.1016/j.colsurfb.2014.11.038

Abstract

In this work, positively charged nanocapsules have been developed for potential ocular delivery exploiting the deposition of PLA onto the droplet surface of a W/O nanoemulsion prepared by the reversed procedure of the PIT method. PLA in combination with different amounts of various oils and surfactants have been studied in order to select the best formulation for polymeric nanocapsule preparation. The traditional visual observation together with the Turbiscan(®) technology were exploited in order to identify the best combination of polymer/oil for nanocapsule preparation. Two different primary surfactants (Span(®) 60 and Span(®) 80) have been tested to select their influence on the field of existence of the nanoemulsion by the construction of the pseudoternary phase diagrams. Cationic hybrid NC have been prepared by the addition of a coating layer of DDAB. The physico-chemical and morphological properties of all the prepared nanocapsules have been evaluated and compared by PCS, DSC and AFM. Therefore, positively charged nanocapsules can be easily prepared by a simple eco-friendly technique that exploits biocompatible materials avoiding a large input of mechanical energy as a potential ocular delivery systems for hydrophilic compounds or gene materials.

Keywords: Cationic lipid; Cationic nanoparticles; Hybrid nanoparticles; Ocular delivery; PLA; Turbiscan.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Carriers / chemistry*
Emulsions
Green Chemistry Technology
Hexoses / chemistry
Lactic Acid / chemistry*
Microscopy, Atomic Force
Nanocapsules / chemistry*
Nanocapsules / ultrastructure
Oils, Volatile / chemistry*
Phase Transition
Polyesters
Polymers / chemistry*
Quaternary Ammonium Compounds / chemistry
Static Electricity
Surface Properties
Surface-Active Agents / chemistry*

Substances

Drug Carriers
Emulsions
Hexoses
Nanocapsules
Oils, Volatile
Polyesters
Polymers
Quaternary Ammonium Compounds
Surface-Active Agents
sorbitan monooleate
didodecyldimethylammonium
Lactic Acid
poly(lactide)
sorbitan monostearate