Primary angiomatoid melanoma as an exceptional morphologic pattern in cutaneous melanoma. A case report and review of the literature
Actas Dermosifiliogr. 2015 Apr;106(3):e13-7.
doi: 10.1016/j.ad.2014.09.002.
Epub 2014 Dec 9.
[Article in
English,
Spanish]
Affiliations
- 1 Departamento de Anatomía Patológica, Hospital Regional Lic. Adolfo López Mateos ISSSTE, México DF, México.
- 2 Departamento de Patología Quirúrgica y Molecular, Centro Médico ABC, México DF, México; Departamento de Biología Celular y Tisular, Universidad Panamericana, México DF, México. Electronic address: cortiz@abchospital.com.
Abstract
We report a case of angiomatoid melanoma on the right thigh of a 59-year-old man. The histologic growth pattern of the tumor mimicked vascular proliferation, and the cells lining the pseudovascular spaces were positive for protein S-100, HMB-45, and MITF-1. The differential diagnosis is with angiosarcoma and pseudovascular adenoid squamous cell carcinoma. The case we present is the fifth reported to date.
Keywords:
Angiomatoid melanoma; Angiosarcoma; HMB-45; Human Melanoma Black-45 (HMB-45); Melanoma angiomatoide; Protein S-100; Proteína S-100.
Copyright © 2014 Elsevier España, S.L.U. y AEDV. All rights reserved.
MeSH terms
-
Adult
-
Aged, 80 and over
-
Carcinoma, Squamous Cell / diagnosis
-
Diagnosis, Differential
-
Hemangiosarcoma / diagnosis
-
Humans
-
Male
-
Melanoma / chemistry
-
Melanoma / diagnosis
-
Melanoma / pathology*
-
Melanoma-Specific Antigens / analysis
-
Microphthalmia-Associated Transcription Factor / analysis
-
Middle Aged
-
Mitotic Index
-
Neoplasm Proteins / analysis
-
S100 Proteins / analysis
-
Skin Neoplasms / chemistry
-
Skin Neoplasms / diagnosis
-
Skin Neoplasms / pathology*
-
gp100 Melanoma Antigen
Substances
-
MITF protein, human
-
Melanoma-Specific Antigens
-
Microphthalmia-Associated Transcription Factor
-
Neoplasm Proteins
-
PMEL protein, human
-
S100 Proteins
-
gp100 Melanoma Antigen