Primary angiomatoid melanoma as an exceptional morphologic pattern in cutaneous melanoma. A case report and review of the literature

Actas Dermosifiliogr. 2015 Apr;106(3):e13-7. doi: 10.1016/j.ad.2014.09.002. Epub 2014 Dec 9.
[Article in English, Spanish]

Abstract

We report a case of angiomatoid melanoma on the right thigh of a 59-year-old man. The histologic growth pattern of the tumor mimicked vascular proliferation, and the cells lining the pseudovascular spaces were positive for protein S-100, HMB-45, and MITF-1. The differential diagnosis is with angiosarcoma and pseudovascular adenoid squamous cell carcinoma. The case we present is the fifth reported to date.

Keywords: Angiomatoid melanoma; Angiosarcoma; HMB-45; Human Melanoma Black-45 (HMB-45); Melanoma angiomatoide; Protein S-100; Proteína S-100.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged, 80 and over
  • Carcinoma, Squamous Cell / diagnosis
  • Diagnosis, Differential
  • Hemangiosarcoma / diagnosis
  • Humans
  • Male
  • Melanoma / chemistry
  • Melanoma / diagnosis
  • Melanoma / pathology*
  • Melanoma-Specific Antigens / analysis
  • Microphthalmia-Associated Transcription Factor / analysis
  • Middle Aged
  • Mitotic Index
  • Neoplasm Proteins / analysis
  • S100 Proteins / analysis
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / pathology*
  • gp100 Melanoma Antigen

Substances

  • MITF protein, human
  • Melanoma-Specific Antigens
  • Microphthalmia-Associated Transcription Factor
  • Neoplasm Proteins
  • PMEL protein, human
  • S100 Proteins
  • gp100 Melanoma Antigen