US valuation of health outcomes measured using the PROMIS-29

Value Health. 2014 Dec;17(8):846-53. doi: 10.1016/j.jval.2014.09.005.


Objectives: Health valuation studies enhance economic evaluations of treatments by estimating the value of health-related quality of life (HRQOL). The Patient-Reported Outcomes Measurement Information System (PROMIS) includes a 29-item short-form HRQOL measure, the PROMIS-29.

Methods: To value PROMIS-29 responses on a quality-adjusted life-year scale, we conducted a national survey (N = 7557) using quota sampling based on the US 2010 Census. Based on 541 paired comparisons with over 350 responses each, pair-specific probabilities were incorporated into a weighted least-squared estimator.

Results: All losses in HRQOL influenced choice; however, respondents valued losses in physical function, anxiety, depression, sleep, and pain more than those in fatigue and social functioning.

Conclusions: This article introduces a novel approach to valuing HRQOL for economic evaluations using paired comparisons and provides a tool to translate PROMIS-29 responses into quality-adjusted life-years.

Keywords: discrete choice experiments; patient-reported outcomes; quality-adjusted life-years.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Anxiety / psychology
  • Choice Behavior*
  • Depression / psychology
  • Fatigue / psychology
  • Female
  • Health Status*
  • Humans
  • Male
  • Middle Aged
  • Models, Economic*
  • Pain / psychology
  • Psychometrics
  • Quality of Life / psychology*
  • Quality-Adjusted Life Years
  • Reproducibility of Results
  • Sleep
  • Socioeconomic Factors
  • Surveys and Questionnaires*
  • Young Adult