Genetic tuning of avian influenza A (H7N9) virus promotes viral fitness within different species

Microbes Infect. 2015 Feb;17(2):118-22. doi: 10.1016/j.micinf.2014.11.010. Epub 2014 Dec 11.


Since their emergence in eastern China, novel influenza A (H7N9) viruses have been continuously circulating in poultry and causing human infections and death. We have proposed a "genetic tuning" mechanism for the genesis and evolution of the novel H7N9 virus during interspecies transmission.

Keywords: Avian influenza A (H7N9) virus; Genetic tuning; Potential hosts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Birds
  • Evolution, Molecular*
  • Genetic Fitness
  • Humans
  • Influenza A Virus, H7N9 Subtype / genetics*
  • Influenza A Virus, H7N9 Subtype / pathogenicity
  • Influenza A Virus, H7N9 Subtype / physiology
  • Influenza in Birds / transmission
  • Influenza in Birds / virology*
  • Influenza, Human / transmission*
  • Influenza, Human / virology*
  • Zoonoses / transmission