Molecular mechanisms governing Arabidopsis iron uptake

Trends Plant Sci. 2015 Feb;20(2):124-33. doi: 10.1016/j.tplants.2014.11.004. Epub 2014 Dec 8.


Plants are the principal source of dietary iron (Fe) for most of Earth's population and Fe deficiency can lead to major health problems. Developing strategies to improve plant Fe content is a challenge because Fe is essential and toxic and therefore regulating Fe uptake is crucial for plant survival. Acquiring soil Fe relies on complex regulatory events that occur in root epidermal cells. We review recent advances in elucidating many aspects of the regulation of Fe acquisition. These include the expanding protein network involved in FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR (FIT)-dependent gene regulation and novel findings on the intracellular trafficking of the Fe transporter IRON-REGULATED TRANSPORTER 1 (IRT1). We outline future challenges and propose strategies, such as exploiting natural variation, to further expand our knowledge.

Keywords: IRT1 trafficking; iron uptake; phytohormones; transcriptional regulation.

Publication types

  • Review

MeSH terms

  • Arabidopsis / genetics*
  • Arabidopsis / metabolism*
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • Cation Transport Proteins / genetics
  • Cation Transport Proteins / metabolism
  • Gene Expression Regulation, Plant*
  • Iron / metabolism*
  • Transcription, Genetic


  • Arabidopsis Proteins
  • Cation Transport Proteins
  • IRT1 protein, Arabidopsis
  • Iron