Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: a double-blinded, randomized, placebo controlled study

J Clin Lipidol. Nov-Dec 2014;8(6):612-617. doi: 10.1016/j.jacl.2014.08.001. Epub 2014 Aug 19.

Abstract

Background: Purified palmitoleic acid (16-1; omega-7) has shown lipid-lowering and anti-inflammatory benefits in open label, epidemiologic, and animal studies.

Objective: Our objective was to perform the first randomized controlled trial of purified palmitoleic acid supplementation in humans.

Methods: Adults with dyslipidemia and evidence of mild systemic inflammation (high-sensitivity C-reactive protein [hs-CRP] between 2 and 5 mg/L) were randomly allocated to receive either 220.5 mg of cis-palmitoleic acid (n = 30) or an identical capsule with placebo (1000 mg of medium chain triglycerides, n = 30) once per day for 30 days. Participants were asked to maintain their current diet. Serum lipids and hs-CRP were drawn at baseline and study completion.

Results: At 30 days, there were significant mean (95% confidence interval [CI]) reductions in CRP (-1.9 [-2.3 to -1.4] mg/L), triglyceride (-30.2 [-40.2 to -25.3] mg/dL), and low-density lipoprotein (LDL) (-8.9 [-12.0 to -5.8] mg/dL), and a significant increase in high-density lipoprotein (HDL) (2.4 [1.5, 3.3] mg/dL) in the intervention group compared with control. These changes equated to 44%, 15%, and 8% reductions in CRP, triglyceride, and LDL respectively, and a 5% increase in HDL compared with control.

Conclusions: Purified palmitoleic acid may be useful in the treatment of hypertriglyceridemia with the beneficial added effects of decreasing LDL and hs-CRP and raising HDL. Further study is needed to elucidate mechanisms and establish appropriate human doses.

Keywords: C-reactive protein; Cholesterol; Hyperlipidemia; Inflammation; Lipids; Omega-7; Palmitoleate; Palmitoleic acid; Supplementation.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • C-Reactive Protein / metabolism
  • Cholesterol, LDL / blood
  • Dietary Supplements
  • Double-Blind Method
  • Dyslipidemias / diet therapy*
  • Fatty Acids, Monounsaturated / adverse effects
  • Fatty Acids, Monounsaturated / therapeutic use*
  • Female
  • Humans
  • Hypolipidemic Agents / adverse effects
  • Hypolipidemic Agents / therapeutic use*
  • Inflammation / diet therapy*
  • Lipid Metabolism / drug effects
  • Male
  • Middle Aged
  • Placebos / administration & dosage
  • Placebos / adverse effects
  • Puerto Rico
  • Triglycerides / blood

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cholesterol, LDL
  • Fatty Acids, Monounsaturated
  • Hypolipidemic Agents
  • Placebos
  • Triglycerides
  • palmitoleic acid
  • C-Reactive Protein