Marked hypertriglyceridemia in a woman receiving metoprolol succinate

J Clin Lipidol. 2014 Nov-Dec;8(6):640-643. doi: 10.1016/j.jacl.2014.07.009. Epub 2014 Jul 15.


β-blockers are commonly used therapies after acute myocardial infarction and in the management of congestive heart failure and hypertension. We report a case of a middle-aged woman with a history of mild hypertension who was placed on metoprolol succinate. Before initiation of the β-blocker, her triglyceride level was in the borderline-high range (150-199 mg/dL). On treatment, her triglyceride levels exceeded 1000 mg/dL. She developed fatigue and mild abdominal discomfort but without biochemical evidence of pancreatitis. After discontinuation of metoprolol succinate, her triglyceride levels receded. This case illustrates an uncommon side effect with a very commonly used therapy in clinical practice. Clinicians should closely evaluate medications and/or other therapies in patients presenting with new-onset hypertriglyceridemia especially when levels are sufficiently elevated to pose increased risk of pancreatitis.

Keywords: Beta-blockers; Hypertriglyceridemia; Metoprolol succinate; Triglycerides.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic beta-Antagonists / adverse effects
  • Adrenergic beta-Antagonists / therapeutic use*
  • Fatty Acids, Omega-3 / administration & dosage*
  • Female
  • Humans
  • Hypertension / complications
  • Hypertension / drug therapy*
  • Hypertriglyceridemia / etiology
  • Hypertriglyceridemia / prevention & control*
  • Metoprolol / adverse effects
  • Metoprolol / analogs & derivatives*
  • Metoprolol / therapeutic use
  • Middle Aged
  • Triglycerides / blood
  • Withholding Treatment


  • Adrenergic beta-Antagonists
  • Fatty Acids, Omega-3
  • Triglycerides
  • Metoprolol