The use of marine-derived bioactive compounds as potential hepatoprotective agents

Acta Pharmacol Sin. 2015 Feb;36(2):158-70. doi: 10.1038/aps.2014.114. Epub 2014 Dec 15.


The marine environment may be explored as a rich source for novel drugs. A number of marine-derived compounds have been isolated and identified, and their therapeutic effects and pharmacological profiles are characterized. In the present review, we highlight the recent studies using marine compounds as potential hepatoprotective agents for the treatment of liver fibrotic diseases and discuss the proposed mechanisms of their activities. In addition, we discuss the significance of similar studies in Oman, where the rich marine life provides a potential for the isolation of novel natural, bioactive products that display therapeutic effects on liver diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Products / pharmacology*
  • Biological Products / therapeutic use*
  • Humans
  • Liver / drug effects*
  • Liver Diseases / drug therapy*
  • Protective Agents / pharmacology*
  • Protective Agents / therapeutic use*


  • Biological Products
  • Protective Agents