Immune escape mechanisms as a guide for cancer immunotherapy

Clin Cancer Res. 2015 Feb 15;21(4):687-92. doi: 10.1158/1078-0432.CCR-14-1860. Epub 2014 Dec 12.


Immunotherapy has demonstrated impressive outcomes for some patients with cancer. However, selecting patients who are most likely to respond to immunotherapy remains a clinical challenge. Here, we discuss immune escape mechanisms exploited by cancer and present strategies for applying this knowledge to improving the efficacy of cancer immunotherapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Immunotherapy / methods*
  • Neoplasms / immunology*
  • Neoplasms / therapy*
  • Tumor Escape / immunology*