Polaprezinc prevents oral mucositis in patients treated with high-dose chemotherapy followed by hematopoietic stem cell transplantation

Anticancer Res. 2014 Dec;34(12):7271-7.


We have previously reported that polaprezinc in sodium alginate suspension (P-AG) inhibited the incidence of oral mucositis induced by radiochemotherapy in patients with head and neck cancer. The present study was designed to investigate whether P-AG prevents oral mucositis in all patients (36 patients) with hematological malignancy receiving high-dose chemotherapy and radiotherapy followed by hematopoietic stem cell transplantation (HSCT). P-AG dramatically reduced the incidence of moderate-to-severe oral mucositis as compared to the control group treated with azulene gargle (20% versus 82% for grade ≥ 2, p<0.01; 0% versus 45% for grade ≥ 3, p<0.01). Pain associated with oral mucositis was also significantly (p=0.004) relieved by P-AG, resulting in a reduction in the use of analgesic agents (28% versus 73%, p=0.025). The incidence of xerostomia and taste disturbance tended to be lowered but not significantly by P-AG. On the other hand, P-AG had no influence on the incidence of other adverse events, tumor remission rate or the survival rate. Therefore, P-AG was found to be highly effective in preventing oral mucositis induced not only by radiochemotherapy for head and neck cancer but also by high-dose chemotherapy and radiotherapy followed by HSCT.

Keywords: Oral mucositis; hematopoietic stem cell transplantation; high-dose chemotherapy; pain; polaprezinc; radiotherapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Ulcer Agents / therapeutic use*
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Carnosine / analogs & derivatives*
  • Carnosine / therapeutic use
  • Female
  • Hematologic Neoplasms / drug therapy
  • Hematologic Neoplasms / radiotherapy
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • Mouth Mucosa / pathology
  • Organometallic Compounds / therapeutic use*
  • Pain Management
  • Retrospective Studies
  • Stomatitis / drug therapy
  • Stomatitis / prevention & control*
  • Taste / drug effects
  • Young Adult
  • Zinc Compounds / therapeutic use


  • Anti-Ulcer Agents
  • Antineoplastic Agents
  • Organometallic Compounds
  • Zinc Compounds
  • polaprezinc
  • Carnosine