Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia

Sci Rep. 2014 Dec 11;4:7431. doi: 10.1038/srep07431.


Helicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori strains from Chinese strains predominantly belong to the hspEAsia subpopulation while Indian/Malay strains mainly belong to the hspIndia subpopulation. By comparing the genome of 27 Asian strains from different subpopulations, we identified six genes associated with risk of H. pylori-induced peptic ulcer disease and gastric cancer. This study serves as an important foundation for future studies aiming to understand the role of bacterial factors in H. pylori-induced gastro-duodenal diseases.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bacterial Outer Membrane Proteins / chemistry
  • Bacterial Outer Membrane Proteins / genetics
  • Fructose-Bisphosphate Aldolase / genetics
  • Gastritis / microbiology*
  • Genes, Bacterial
  • Genetic Association Studies
  • Genetic Variation
  • Helicobacter Infections / microbiology*
  • Helicobacter pylori / genetics*
  • Humans
  • Malaysia
  • Molecular Sequence Data
  • Multilocus Sequence Typing
  • Peptic Ulcer / microbiology*
  • Phylogeny
  • Stomach Neoplasms / microbiology*


  • Bacterial Outer Membrane Proteins
  • Fructose-Bisphosphate Aldolase