Anti-allergic effect of intranasal administration of type-A procyanidin polyphenols based standardized extract of cinnamon bark in ovalbumin sensitized BALB/c mice

Phytother Res. 2015 Mar;29(3):423-33. doi: 10.1002/ptr.5269. Epub 2014 Dec 12.


The objective of the present work was to evaluate anti-allergic effects of intranasal administration of type-A procynidines polyphenols (TAPP) based standardized hydroalcoholic extract of Cinnamomum zeylanicum bark (TAPP-CZ) in ovalbumin (OVA)-induced experimental allergic rhinitis (AR) in BALB/c mice. Sixty male BALB/c mice were divided into six groups of ten each (G1-G6). The mice from G1 were nonsensitized and maintained as normal group. Remaining mice (G2-G6) were sensitized with OVA (500 μL solution, intraperitoneal) on alternate days for 13 days and had twice daily intranasal treatment from day 14-21 as follows: G2 (AR control) received saline, G3 (positive control, XLY) received xylometazoline (0.5 mg/mL, 20 μL/nostril) and G4-G6 received TAPP-CZ (3, 10 and 30 µg/kg in nostril), respectively. On day 21, mice were challenged with OVA (5 μL/nostril, 5% solution) and assessments (nasal signs, biochemical and histopathological) were performed. Treatment with TAPP-CZ (10 and 30 µg/kg in nostril) showed significant attenuation in OVA-induced alterations of the nasal (number of nasal rubbing and sneezing), biochemical markers (serum IgE and histamine), haematological, morphological (relative organ weight of spleen and lung) and histopathological (nasal mucosa and spleen) parameters. In conclusion, TAPP-CZ showed anti-allergic efficacy in animal model of AR.

Keywords: Cinnamomum zeylanicum bark; allergic rhinitis; histamine; ovalbumin; type-A procyanidin polyphenols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intranasal
  • Animals
  • Anti-Allergic Agents / pharmacology*
  • Biflavonoids / pharmacology*
  • Catechin / pharmacology*
  • Cinnamomum zeylanicum / chemistry*
  • Disease Models, Animal
  • Histamine / blood
  • Immunoglobulin E / blood
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Ovalbumin
  • Plant Bark / chemistry
  • Plant Extracts / pharmacology*
  • Polyphenols / pharmacology*
  • Proanthocyanidins / pharmacology*
  • Rhinitis, Allergic / drug therapy*
  • Sneezing


  • Anti-Allergic Agents
  • Biflavonoids
  • Plant Extracts
  • Polyphenols
  • Proanthocyanidins
  • Immunoglobulin E
  • procyanidin
  • Histamine
  • Catechin
  • Ovalbumin