Disruption of the blood-brain barrier caused by nonionic contrast medium used for abdominal angiography: CT demonstration

J Comput Assist Tomogr. 1989 Sep-Oct;13(5):893-5. doi: 10.1097/00004728-198909000-00027.


We describe a case of disruption of the blood-brain barrier (BBB) by nonionic, low osmolality contrast medium after abdominal angiography. One plausible explanation of this event is that acute hypertension during angiography may have increased the BBB permeability, allowing the contrast medium to leak across it.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Angiography
  • Blood-Brain Barrier / drug effects*
  • Carcinoma, Hepatocellular / diagnostic imaging
  • Extravasation of Diagnostic and Therapeutic Materials*
  • Humans
  • Iohexol / adverse effects*
  • Liver Neoplasms / diagnostic imaging
  • Male
  • Tomography, X-Ray Computed


  • Iohexol