Mushrooms: a potential natural source of anti-inflammatory compounds for medical applications

Mediators Inflamm. 2014:2014:805841. doi: 10.1155/2014/805841. Epub 2014 Nov 23.


For centuries, macrofungi have been used as food and medicine in different parts of the world. This is mainly attributed to their nutritional value as a potential source of carbohydrates, proteins, amino acids, and minerals. In addition, they also include many bioactive metabolites which make mushrooms and truffles common components in folk medicine, especially in Africa, the Middle East, China, and Japan. The reported medicinal effects of mushrooms include anti-inflammatory effects, with anti-inflammatory compounds of mushrooms comprising a highly diversified group in terms of their chemical structure. They include polysaccharides, terpenoids, phenolic compounds, and many other low molecular weight molecules. The aims of this review are to report the different types of bioactive metabolites and their relevant producers, as well as the different mechanisms of action of mushroom compounds as potent anti-inflammatory agents.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Agaricales / chemistry*
  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / therapeutic use
  • Cell Line
  • Fungi / chemistry*
  • Humans
  • Inflammation / drug therapy*
  • Inhibitory Concentration 50
  • Mice
  • Models, Chemical
  • Molecular Conformation
  • Peptides / chemistry
  • Polysaccharides / chemistry
  • Signal Transduction


  • Anti-Inflammatory Agents
  • Peptides
  • Polysaccharides