Accelerating immune reconstitution after hematopoietic stem cell transplantation

Clin Transl Immunology. 2014 Feb 28;3(2):e11. doi: 10.1038/cti.2014.2. eCollection 2014 Feb.


Viral infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation. Pharmacologic agents are effective against some pathogens, but they are costly and can be associated with significant toxicities. Thus, many groups have investigated adoptive T-cell transfer as a means of hastening immune reconstitution and preventing and treating viral infections. This review discusses the immunotherapeutic strategies that have been explored.

Keywords: T cells; adoptive immunotherapy; hematopoietic stem cell transplantation; viral infections.

Publication types

  • Review