Inositol phosphates and cell signalling

Nature. 1989 Sep 21;341(6239):197-205. doi: 10.1038/341197a0.


Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / physiology*
  • Cell Membrane / physiology
  • Humans
  • Inositol Phosphates / physiology*
  • Lithium / pharmacology
  • Phosphatidylinositols / physiology*
  • Sugar Phosphates / physiology*


  • Inositol Phosphates
  • Phosphatidylinositols
  • Sugar Phosphates
  • Lithium
  • Calcium