[Participation of Agouti related peptide in machanisms of wakefulness-sleep cycle regulation]

Fiziol Cheloveka. Nov-Dec 2013;39(6):24-30.
[Article in Russian]


Agouti-related protein (AGRP) is expresses in hypothalamic neurons in human and animals. Immunohistochemical study in rats Wistar rats demonstrates significant changes AGRP optical density in the neurons of arcuate hypothalamic nucleus as well as in processes in the hypothalamus and nucleus accumbens after the 6 hours of sleep deprivation (increase) and after 2 hours of post-deprivative sleep (decrease). Comparison of these results with earlier obtained shows the opposite trend changes in AGRP optical density and speed limiting enzyme of dopamine synthesis-tyrosine hydroxylase in the hypothalamus and in striatonigral system. The increase of AGRP was accompanied by a decrease of tyrosine hydroxylase and the decrease of AGRP, apposite, it increases. The obtained data demonstrate the role ofAGRP as a modulator of the functional activity of the dopaminergic brain neurons. The problem of the relationship of various functions of organism (food behavior, sleep, stress) is discusses by their participation in the regulation of the same neurotransmitter systems.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agouti-Related Protein / metabolism*
  • Animals
  • Dopamine / metabolism
  • Dopaminergic Neurons / cytology
  • Dopaminergic Neurons / metabolism*
  • Humans
  • Hypothalamus / cytology
  • Hypothalamus / metabolism*
  • Male
  • Nerve Tissue Proteins / metabolism*
  • Nucleus Accumbens / cytology
  • Nucleus Accumbens / metabolism*
  • Rats
  • Rats, Wistar
  • Sleep / physiology*


  • AGRP protein, rat
  • Agouti-Related Protein
  • Nerve Tissue Proteins
  • Dopamine