Differences in brachial and femoral artery responses to prolonged sitting

Cardiovasc Ultrasound. 2014 Dec 15;12:50. doi: 10.1186/1476-7120-12-50.


Introduction: It is unknown if there are limb differences in vascular function during prolonged sitting.

Purpose: This study was designed to test whether the effects of prolonged sitting on brachial artery (BA) and the superficial femoral artery (SFA) are similar.

Methods: Twelve men (24.2 ± 4 yrs.) participated in a 3 hr prolonged sitting trial (SIT). SFA and BA flow mediated dilation (FMD) and respective flow patterns were measured at baseline, 1 hr, 2 hr and 3 hr.

Results: By a one-way ANOVA there was a significant decline in SFA FMD during 3 hrs of SIT (p < 0.001). Simultaneously, there was a significant decline in antegrade (p = 0.04) and mean (0.037) shear rates. By a one way ANOVA there were no significant differences in BA FMD during 3 hrs of sitting. There were no changes in the shear rates in the BA except for a significant decrease in antegrade shear rate (p = 0.029) and a significant increase in oscillatory shear index (p = 0.034) during 3 hrs of sitting. Furthermore, there was no correlation between BA and SFA FMD measurements.

Conclusion: Three hours of sitting resulted in impaired SFA FMD but not BA FMD. Although 3 hours of sitting did not impair BA FMD, it impaired shear patterns in the BA.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological / physiology*
  • Blood Flow Velocity / physiology*
  • Blood Pressure / physiology*
  • Brachial Artery / diagnostic imaging
  • Brachial Artery / physiology*
  • Elastic Modulus / physiology
  • Femoral Artery / diagnostic imaging
  • Femoral Artery / physiology*
  • Humans
  • Male
  • Posture / physiology*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Shear Strength / physiology
  • Ultrasonography
  • Vascular Resistance / physiology
  • Vascular Stiffness / physiology
  • Young Adult