Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

Biochem Biophys Res Commun. 1989 Sep 29;163(3):1450-5. doi: 10.1016/0006-291x(89)91141-8.


Immunoblotting studies on mitochondria prepared from the striata of patients who died of Parkinson's disease were performed using specific antisera against Complexes I, III and IV. In 4 out of 5 patients with Parkinson's disease, the 30-, 25- and 24-kDa subunits of Complex I were moderately to markedly decreased. No clear difference was noted in immunoblotting studies on subunits of Complexes III and IV between the control and Parkinson's disease. Deficiencies in Complex I subunits seem to be one of the most important clues to elucidate pathogenesis of Parkinson's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Corpus Striatum / enzymology*
  • Electron Transport Complex III / isolation & purification
  • Electron Transport Complex IV / isolation & purification
  • Humans
  • Immunoblotting
  • Macromolecular Substances
  • Mitochondria / enzymology*
  • NAD(P)H Dehydrogenase (Quinone)
  • Oxygen Consumption
  • Parkinson Disease / enzymology*
  • Quinone Reductases / deficiency*
  • Quinone Reductases / isolation & purification
  • Quinone Reductases / metabolism
  • Reference Values


  • Macromolecular Substances
  • NAD(P)H Dehydrogenase (Quinone)
  • Quinone Reductases
  • Electron Transport Complex IV
  • Electron Transport Complex III