Possible involvement of Epstein-Barr virus (EBV) in polyclonal B-cell activation in Sjögren's syndrome

J Autoimmun. 1989 Aug;2(4):427-32. doi: 10.1016/0896-8411(89)90171-6.

Abstract

The following results suggest that EBV might be involved in the mechanism of polyclonal B-cell activation of Sjögren's syndrome (SS). (1) The levels of serum anti-VCA antibodies of both IgG and IgM class were significantly elevated in SS. (2) Excretion of EBV from the oropharynx was frequently observed in SS. (3) Spontaneously transformed B-cell lines producing a large amount of transforming EBV were established preferentially from SS. (4) An EBV-specific regulatory mechanism was impaired in SS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Viral / immunology*
  • Antigens, Viral / immunology
  • Autoimmune Diseases / complications*
  • Autoimmune Diseases / immunology
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / pathology
  • Capsid Proteins*
  • Cell Transformation, Viral
  • Female
  • Herpesviridae Infections / complications*
  • Herpesviridae Infections / immunology
  • Herpesvirus 4, Human / immunology*
  • Herpesvirus 4, Human / isolation & purification
  • Humans
  • Lymphocyte Activation
  • Middle Aged
  • Oropharynx / microbiology
  • Sjogren's Syndrome / complications*
  • Sjogren's Syndrome / immunology
  • Sjogren's Syndrome / microbiology

Substances

  • Antibodies, Viral
  • Antigens, Viral
  • Capsid Proteins
  • Epstein-Barr viral capsid antigen