Fatal Anaphylactic Shock Ceftriaxone-Induced in a 4-Year-Old Child

Pediatr Emerg Care. 2016 Jan;32(1):32-3. doi: 10.1097/PEC.0000000000000311.


One of the most used cephalosporin in clinical practice is ceftriaxone. Anaphylaxis due to the administration of ceftriaxone is considered a rare event. Here, we report a case of fatal anaphylactic shock after the administration of ceftriaxone in a child who had tolerated the drug in past exposures. The allergic pathogenesis is sustained by the clinical data (short time between the inoculation of the drug and the onset of the symptoms; past exposure to the same molecule and probable sensitization) and the postmortem examination findings (polivisceral congestion and intense eosinophilia found in the histological examination).

Publication types

  • Case Reports

MeSH terms

  • Anaphylaxis / chemically induced*
  • Anaphylaxis / diagnosis
  • Anaphylaxis / immunology
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / immunology
  • Autopsy / methods
  • Ceftriaxone / adverse effects*
  • Ceftriaxone / immunology
  • Child, Preschool
  • Drug Hypersensitivity / etiology*
  • Drug Hypersensitivity / immunology
  • Fatal Outcome
  • Humans
  • Male
  • Retrospective Studies


  • Anti-Bacterial Agents
  • Ceftriaxone