Face-mask CPAP and sodium bicarbonate infusion in acute, severe asthma and metabolic acidosis

Chest. 1989 Oct;96(4):943-4. doi: 10.1378/chest.96.4.943.


A patient with a history of previous mechanical ventilation for asthma was hospitalized with acute, severe asthma; metabolic acidosis; and hyperlactatemia. In addition to standard therapy, she was successfully treated with face-mask CPAP and IV sodium bicarbonate infusion. This therapy may help prevent mechanical ventilation in some patients with acute, severe asthma and lactic acidosis.

Publication types

  • Case Reports

MeSH terms

  • Acidosis, Lactic / therapy*
  • Adult
  • Asthma / therapy*
  • Bicarbonates / therapeutic use*
  • Female
  • Humans
  • Infusions, Intravenous
  • Positive-Pressure Respiration / methods*
  • Sodium / therapeutic use*
  • Sodium Bicarbonate


  • Bicarbonates
  • Sodium Bicarbonate
  • Sodium