Role of probiotics and functional foods in health: gut immune stimulation by two probiotic strains and a potential probiotic yoghurt

Endocr Metab Immune Disord Drug Targets. 2015;15(1):37-45. doi: 10.2174/1871530314666141216121349.


There are numerous reports that show the benefits on the health attributed to the probiotic consumptions. Most of the studies were performed using animal models and only some of them were validated in controlled human trials. The present review is divided in two sections. In the first section we describe how the probiotic microorganisms can interact with the intestinal epithelial cells that are the first line of cell in the mucosal site, focusing in the studies of two probiotic strains: Lactobacillus casei DN-114001 (actually Lactobacillus paracasei CNCMI-1518) and Lactobacillus casei CRL 431. Then we describe same beneficial effects attributed to probiotic administration and the administration of fermented milks containing these microorganisms or potential probiotic yoghurt, principally on the immune system and on the intestinal barrier in different experimental mouse models like enteropathogenic infection, malnutrition, cancer and intestinal inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Functional Food*
  • Gastric Mucosa / immunology*
  • Gastric Mucosa / microbiology
  • Gastrointestinal Microbiome / physiology*
  • Health Status
  • Humans
  • Probiotics / administration & dosage*
  • Probiotics / metabolism
  • Yogurt* / microbiology