Balance and imbalance in the immune system: life on the edge

Immunity. 2014 Nov 20;41(5):682-4. doi: 10.1016/j.immuni.2014.11.005. Epub 2014 Nov 20.


CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • CTLA-4 Antigen / genetics*
  • Female
  • Germ-Line Mutation*
  • Haploinsufficiency*
  • Humans
  • Immune System Diseases / genetics*
  • Immunity / genetics*
  • Male


  • CTLA-4 Antigen