Hepatitis E in developed countries: current status and future perspectives

Future Microbiol. 2014;9(12):1361-72. doi: 10.2217/fmb.14.89.


Hepatitis E virus (HEV) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. Recent studies have shown that HEV causes acute and chronic infection in developed countries. In these geographical settings, HEV is primarily a porcine zoonosis caused by genotypes 3 (HEV3) and 4 (HEV4). The clinical phenotype of hepatitis E continues to emerge, and recent data show that HEV is associated with a range of neurological syndromes including Guillain-Barré syndrome and neuralgic amytrophy.

Keywords: chronic infection; cirrhosis; hepatitis; hepatitis E; pigs; zoonosis.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Chronic Disease
  • Developed Countries*
  • Developing Countries
  • Female
  • Genotype
  • Hepatitis E / complications
  • Hepatitis E / drug therapy
  • Hepatitis E / epidemiology*
  • Hepatitis E / virology
  • Hepatitis E virus / genetics
  • Humans
  • Male
  • Nervous System Diseases / etiology
  • Swine
  • Zoonoses